Sometimes unconfessed sin is the cause of our burdens. When this happens we must repent.      

Psalm 38:4-6 My guilt overwhelms me–it is a burden too heavy to bear. My wounds fester and stink because of my foolish sins. I am bent over and racked with pain. All day long I walk around filled with grief.

Psalm 40:11-12 Withhold not thou thy tender mercies from me, O LORD: let thy lovingkindness and thy truth continually preserve me. For innumerable evils have compassed me about: mine iniquities have taken hold upon me, so that I am not able to look up; they are more than the hairs of mine head: therefore my heart faileth me.